Researchers have mapped 90 percent of the human proteome, which could inform the development of new medicines.

An international research team has mapped the first draft sequence of the human proteome. The research team say that as many human diseases result from changes in the composition or functions of proteins, mapping the proteome strengthens the foundation for disease diagnosis, prediction of outcomes, treatment and precision medicine.

“Today marks a significant milestone in our overall understanding of human life,” said Professor Chris Overall, from the University of British Columbia, Canada. “Whereas the human genome provides a complete ‘blueprint’ of human genes, the human proteome identifies the individual building blocks of life encoded by this blueprint: proteins. Proteins interact to shape everything from life-threatening diseases to cellular structure in our bodies.”

With 90 percent of the proteins in the human body now mapped, Overall said scientists have a deeper understanding of how individual proteins interact to influence human health, providing insights into disease prevention and individualised medicine. The researchers also say their work may have implications for scientists studying potential treatments for COVID-19.

“In COVID-19, for instance, there are two proteomes involved, that of the SARS-CoV-2 virus and that of the infected cells, both of which likely interact with, modify and change the function of the other,” commented Overall. “Understanding this relationship can shed light on why some cells and individuals are more resilient to COVID-19 and others more vulnerable, providing essential functional information about the human body that genomics alone cannot answer.”

The team highlight that this map of the proteome could aid in disease diagnosis, prognosis, treatment and precision medicine.

“Humans share 99.9 percent of their DNA between individuals, yet deficiencies in the proteome ‘parts’ stemming from inherited genetic mutations can lead to genetic diseases, or defective or inadequate immune and cellular responses to environmental, nutritional and infection stressors,” said Overall. “Knowing which proteins are key to protection from disease and the deficiencies in expression or activity that are hallmarks of disease, can inform individualised medicine and the development of new therapies.”

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorised as “Necessary” are stored on your browser as they are as essential for the working of basic functionalities of the website. For our other types of cookies “Advertising & Targeting”, “Analytics” and “Performance”, these help us analyse and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these different types of cookies. But opting out of some of these cookies may have an effect on your browsing experience. You can adjust the available sliders to ‘Enabled’ or ‘Disabled’, then click ‘Save and Accept’. View our Cookie Policy page.

Necessary cookies enable the core functionality of the website, including security, network management and accessibility. These cookies do not store any personal information. You may disable these by changing your browser settings, but this may affect how the website functions.

Analytics cookies collect information about your use of the content, and in combination with previously collected information, are used to measure, understand, and report on your usage of this website.

Performance cookies include cookies that deliver enhanced functionalities of the website, such as caching. These cookies do not store any personal information.

Source: https://www.drugtargetreview.com/news/74591/first-draft-sequence-of-human-proteome-released/

Proteome, Research, Human, Protein

World news – CA – First draft sequence of human proteome released – Drug Target Review

En s’appuyant sur ses expertises dans les domaines du digital, des technologies et des process , CSS Engineering vous accompagne dans vos chantiers de transformation les plus ambitieux et vous aide Ă  faire Ă©merger de nouvelles idĂ©es, de nouvelles offres, de nouveaux modes de collaboration, de nouvelles maniĂšres de produire et de vendre.

CSS Engineering s’implique dans les projets de chaque client comme si c’était les siens. Nous croyons qu’une sociĂ©tĂ© de conseil devrait ĂȘtre plus que d’un conseiller. Nous nous mettons Ă  la place de nos clients, pour aligner nos incitations Ă  leurs objectifs, et collaborer pour dĂ©bloquer le plein potentiel de leur entreprise. Cela Ă©tablit des relations profondes et agrĂ©ables.

Nos services:

  1. Création des sites web professionnels
  2. Hébergement web haute performance et illimité
  3. Vente et installation des caméras de vidéo surveillance
  4. Vente et installation des systĂšme de sĂ©curitĂ© et d’alarme
  5. E-Marketing

Toutes nos réalisations ici https://www.css-engineering.com/en/works/

Previous articleThe long wait for Google’s $2.1 billion Fitbit deal
Next articleDoom Eternal: The Ancient Gods Has Been Released
Georges MOMO
Georges MOMO est IngĂ©nieur informatique ( DiplĂŽme obtenu Ă  3IL Limoges France) Il dĂ©but sa carriĂšre par un stage de fin d'Ă©tude d'ingĂ©nieur Ă  Toulouse sur un projet de AIRBUS Toulouse Blagnac, il enchaĂźne ensuite Ă  Nantes oĂč il travaille sur le projet de la migration documentaire de la BPCE. Son ambition le conduit ensuite Ă  Paris oĂč il travaille sur deux projets de la banque de France (Validation des titres de bourse Ă©mis sur le marchĂ© europĂ©en et la gĂ©nĂ©ration centralisĂ©e des documents) qu'il quitte quelques annĂ©es plus tard occupant le poste de responsable technique. PassionnĂ© de l'information, il est actif sur le web et sur le terrain depuis les annĂ©es 2000.

LEAVE A REPLY

Please enter your comment!
Please enter your name here