August 31, 2020 — Arrakis Therapeutics is touting the publication of a new paper that demonstrates the capabilities of its proprietary Photoaffinity Evaluation of RNA Ligation-sequencing (PEARL-seq) technology for the systemic identification of binding sites in RNA molecules as a method to facilitate the discovery of RNA-targeted small molecule medicines. The research was published in the American Chemical Society’s ACS Chemical Biology.

The company’s PEARL-seq utilizes photoaffinity labeling of RNA in combination with next-generation sequencing and a dedicated bioinformatic analysis pipeline. The data shows that the PEARL-seq platform was able to identify ligand binding sites within a model aptamer RNA and identify potential off-target binding interactions.

The platformin combination with conventional RNA structure probing methodscan be used to generate and refine 2D and 3D structures of RNA-small molecule complexes to facilitate the rational design of RNA-targeted small molecule therapeutics, according to the company.

Source: https://www.scienceboard.net/index.aspx?sec=log&URL=https%3A%2F%2Fwww.scienceboard.net%2Findex.aspx%3Fsec%3Dsup%26sub%3Dgen%26pag%3Ddis%26ItemID%3D1266

World news – US – Arrakis touts paper on RNA-targeted small molecules

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Georges MOMO
Georges MOMO is Computer Engineer ( Graduated in 3EV Limoges France) He began his career with an internship engineering study in Toulouse on a draft AIRBUS Toulouse Blagnac, It then connects to Nantes, where he worked on the project of documentary migration BPCE. His ambition then it leads to Paris where he worked on two projects of the Bank of France (Validation of trading securities on the European market and centralized document generation) he left a few years later held the position of Technical Manager. Passionate information, it is active on the web and on the field since the 2000.

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